AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model
Abstract Background Ischemic cardiomyopathy and resultant heart failure Tools (HF) is a significant cause of morbidity and mortality worldwide.Downregulation of cardiac bridging integrator 1 (cBIN1), a membrane scaffolding protein responsible for organizing t-tubules and organizing the calcium handing apparatus, occurs in progressive HF.Therefore,